Arecaidine has tumorgenicity.

Tubulin Inhibitor 11 is a potent, orally active agent that inhibits tubulin by targeting the Colchicine binding site. It impedes tubulin polymerization, leading to mitotic blockade and apoptosis.

Methylacetoacetic acid has been identified in the urine of patients with an inherited deficiency of propionyl-CoA carboxylase and after isoleucine loading in the diagnosis of 2-methylacetoacetyl-CoA thiolase deficiency.